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Post Approval Study of Lixelle for the Treament of Dialysis-Related Amyloidosis

Reward Compensation may be available — see study details

Dialysis-related amyloidosis (DRA) is a serious complication of long-term hemodialysis (HD). Its pathogenic mechanism involves accumulation of β2-microglobulin (β2M) in the blood. β2M is produced by most cells in the body and is metabolized in the kidney in healthy individuals. However, in HD patients with renal dysfunction, β2M which is not removed entirely by HD accumulates excessively in the blood. Then it forms amyloid fibrils that are deposited in bones, joints, and soft tissues. The fibrils are further modified by advanced glycation end products (AGE), inducing local macrophage infiltration and production of cytokines leading to chronic inflammation and activation of osteoclasts. Cons…

Reward Compensation may be available — see study details
Category Paid Research Studies
Location New York
Eligibility Currently recruiting U.S. participants. Eligibility varies by study — review the criteria and contact the study team. Compensation is mentioned for this study; the amount is set by the researchers.
Source Official Source ↗
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